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Comparative Immunologic Response in Rabbits Following the Injection of Heat-Killed Pasteurella Avicida by Several Routes and of Sonic Disintegrated P. Avicida Intracutaneously

From the William Pepper Laboratory and the Department of Medicine of the University of Pennsylvania

Abstract

1. The intravenous injection of heat-killed Pasteurella avicida gives a better agglutinin-response and protective resistance than either the subcutaneous or intracutaneous route.

2. A comparative study of inoculations given intracutaneously into the back, intracutaneously into the inner aspect of the thigh, subcutaneously into the back and subcutaneously into the inner aspect of the thigh, showed no superiority of any one site or route in ability to produce resistance to the infection following an intraabdominal inoculation of 1,000 lethal doses of P. avicida. The agglutinin-titers were somewhat higher in the animals injected intracutaneously, whether in the back or the thigh, than in the animals injected subcutaneously.

3. Under the conditions of this experiment, the filtrate of live Pasteurella disintegrated by sonic vibration is a poor antigen when injected intracutaneously into the back.

4. No significant difference in sensitization by the various routes of injection was noted in this experiment using P. avicida as an antigen.