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Neutralization of Virus of Myxoma by Specific Immune Serum

From the Department of Medicine of Western Reserve University, School of Medicine, and the Lakeside Hospital, Cleveland

Abstract

In a previous study of infectious myxoma (1) it was found that the results of multiple intradermal inoculations of the virus were consistent with the hypothesis that infection follows the suitable introduction of a single viral particle. The implications of this quantal response were pointed out as they bore on the problem of titrating virus, and it was shown that by proper procedures accurate estimates could be made of the quantity of virus present in a suspension of it. In the present investigation the method has been extended to a study of the neutralization of virus by the serum of animals convalescent from infection.

Because of the extremely high mortality of the disease, studies of the phenomena of immunity have been restricted. However, Hobbs (2) in 1931 demonstrated that the serum of an animal convalescent from myxoma was capable of neutralizing the active agent.