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Studies Concerning Possible Mechanisms Involved in Experimental Serum Sickness¹

From the Department of Bacteriology, St. Louis University School of Medicine, St. Louis, Missouri

Abstract

Experimental serum-sickness in the rabbit is not affected in its time of inception, incidence or duration by the parenteral administration of histaminase. Likewise, the administration of rabbit antihorse serum to horse-serum-injected-rabbits failed to alter the development of the reaction of serum-sickness upon the animals' ears.

By the injection of a small amount of horse-serum into rabbit ear-tissue, followed later by the administration elsewhere of rabbit antihorse serum, it was possible to elicit a local serum-reaction at the prepared ear-site. This local serum-reaction was not elicited by heat-alkali processed horse-serum when comparable quantities of the antiserum were administered; reactions were elicited however by larger amounts of antiserum.

The indication is afforded that heat-alkali treatment of serum serves to quantitatively reduce, rather than to destroy or remove, a factor in horse-serum upon which experimental serum-sickness may depend.

Footnotes

¹ A preliminary account of these experiments was presented before the twenty-seventh annual meeting of the American Association of Immunologists at New Orleans, March 13, 1940.