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Report of a Trial of a New Schick-Toxin

From the Laboratory of Hygiene, Department of Pensions and National Health, Canada

Abstract

A change in the specifications for the preparation of diphtherial toxin for use in the performance of the Schick-test has been advocated by Taylor and Moloney (1). The material they propose for use in this test differs from that specified by the Permanent Commission on Biological Standards of the League of Nations and incorporated in the Regulations under the Food and Drugs Act of Canada, in that it is made from "fresh" toxin (less than one year old and free from preservative) and that it has twice the toxicity and a lower antitoxin combining power (one dose neutralized by 1/1250, but not by 1/1500 unit of antitoxin). It is their contention that such material will increase the percentage of interpretable reactions, especially in those cases where the individual is a reactor to diphtheric protein.

The following brief report outlines our experience in a trial of material prepared according to Taylor and Moloney's specifications.