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The Serological Reactivity of Nucleic Acid¹

From the Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

The reaction of nucleic acids with certain antibacterial sera has been studied and the following points made:

1. Nucleic acids give a specific precipitate with certain antisera, in particular equine antipneumococcic sera.

2. The reactive substance is in the euglobulin fraction of the serum.

3. The reaction is sensitive to changes in ionic strength. Also for a given ionic strength there is a difference in the amount of precipitate obtained when different ions are present.

4. The reaction is specifically inhibited under suitable conditions by purine nucleotides, purine nucleosides and purine bases. Pyrimidine bases show only weak inhibition and pentoses and phosphates do not inhibit the reaction at all.

Footnotes

¹ The expenses of this work have been defrayed by a generous grant from the Commonwealth Fund. An interim report of this work was made at the Forty-First General Meeting of the Society of American Bacteriologists; J. Bact., 1940, 39, 32.