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The Journal of Immunology, 1940, 39: 543-554.
Copyright © 1940 by The American Association of Immunologists, Inc.
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The Organ-Specificity of Brain-Broth as Shown by Passive Anaphylaxis in Guinea-Pigs1

G. Howard Bailey and Raymond E. Gardner

From the Department of Immunology, Laboratories of Immunology and Filterable Viruses, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland

Abstract

1. Prolonged immunization of rabbits with a sedimented, heat-killed vaccine of Past. boviseptica grown in an infusion broth made from rabbit-brain, caused the formation of antibodies not only to the bacteria but also to the broth.
2. Guinea-pigs prepared by intraäbdominal injection of such an antibrain serum were passively sensitized so that fatal anaphylaxis was obtained 24 hours later by intravenous injection of an autoclaved aqueous extract of rabbit-brain, a definite reaction with extract of testicle, while very slight or negative reactions resulted from injections of such extracts made from other organs of the rabbit.
3. Guinea-pigs prepared and tested in the same manner, reacted with severe or fatal anaphylaxis when injected with autoclaved aqueous extracts of the brains of the frog, duck, opossum, mouse, rat, guinea-pig, rabbit, ferret, cat, dog, hog, sheep, goat, ox, monkey, and man, but showed little or no reaction to the extracts of fish and chicken brains.
4. The thermostable, water-soluble antigen of autoclaved brain is organ-specific but not species-specific. There are some indications that it may be a derivative of a brain-protein.

Footnotes

1 This work was supported in part by a grant-in-aid from the National Research Council.






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