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Hemolytic Effect of Typhoid Cultures in Combination with Pure Lines of Bacteriophage¹

From the Bacteriological Laboratories of Beth Israel Hospital, New York, N. Y.

Abstract

In the presence of a specific bacteriophage, typhoid bacilli grow hemolytically on sheep blood plates. This phenomenon was analyzed by means of pure line bacteriophages with specific affinities. Pure line phages specific for the O, R, Vi and H-antigens, respectively, cause hemolysis when combined with homologous typhoid cultures. Salmonella strains carrying the corresponding antigens react in the same way as typhoid cultures as far as phage bacteriolysis is concerned. They differ, however, as to hemolysis. In most of them, phage lysis is not accompanied by hemolysis. The hemolytic effect, therefore, depends: (a) Upon an inherent quality of the culture. (b) Upon a bacteriolytic phage effect of sufficient strength.

In presence of the Vi-antigen the hemolytic effect of the O-phage is suppressed.

Footnotes

¹ Aided by a grant from the Committee on Scientific Research of American Medical Association.