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Studies of the Early Stage of Resistance to Pneumococcic Infection

II. TYPE-SPECIFICITY AND HUMORAL IMMUNE BODY PRODUCTION

From the Department of Bacteriology, University of Pittsburgh, and the Institute of Pathology, The Western Pennsylvania Hospital, Pittsburgh, Pennsylvania

Abstract

The early stage of resistance to infection by a type I pneumococcus may be elicited within 48 to 72 hours in response to intracutaneous treatment with the homologous type I vaccine, but not in response to the heterologous type III vaccine.

Small quantities of mouse-protective substances are demonstrable in the blood of slightly more than half of the resistant animals by the sixth and tenth days following a single intracutaneous immunizing injection; they are not present in demonstrable quantities as early as the second and third days following this treatment. No increase in agglutinins could be demonstrated during the early stage of resistance.