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Studies on in Vitro Anaphylaxis and Release of an Active Non-Histamine Material from Sensitized Guinea Pig Lung¹

Departments of Bacteriology and Parasitology, and Physiology, University of Chicago, Chicago, Illinois

Abstract

The foregoing experiments show:

1. That rat uteri, which are unaffected by ordinary doses of histamine, respond to some substance released by sensitized guinea-pig lung-tissue during anaphylactic shock.

2. That sensitized circular and longitudinal uterine muscle from pregnant guinea pigs readily shows anaphylaxis and that the latter are just as sensitive and show a more severe type of reaction than virgin uterine muscle.

3. That tissues, particularly intestinal, taken from 7 to 8 week foetuses of sensitized mothers, show a hypersensitive condition.

Footnotes

¹ This investigation was aided by a grant from the Dr. Wallace and Clara A. Abbott Memorial Fund of the University of Chicago.