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The Reticulo-Endothelial System and Immunity in Hog-Cholera¹

Division of Veterinary Medicine, Minnesota Agricultural Experiment Station, University Farm, St. Paul

Abstract

The artificial immunization of swine against hog-cholera has been carried on to a greater or lesser extent in this and other countries for the past quarter century. in general, the results have been satisfactory, and especially when adequate doses of antiserum of good quality and antigen of high virulence are used to treat swine that are free from disease and are of weaning age (forty to fifty days) or over. Under these conditions an active immunity of a high order is produced and usually considered to be of lifelong duration. Not infrequently, however, even where the factors attendant upon its success have apparently been fulfilled, either no immunity is produced or the immunity is of a lower order and short duration. The reason for these occurrences is not known. It seems rational to suspect that it rests in the mechanism of the body responsible for the development of immunity.

Footnotes

¹ Paper No. 1805, Scientific Journal Series, Minnesota Agricultural Experiment Station.