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Experimental Immunization of Mice with the Virus of Epidemic Influenza

II. Immunity After Intranasal Inoculation of Mouse-Passage, Tissue-Culture, and Ferret-Passage Strains

Laboratories of the International Health Division of The Rockefeller Foundation, New York and The Research Laboratory of The California State Department of Public Health, Berkeley, California

Abstract

Mice inoculated intranasally with mouse-adapted strains of influenza-virus develop immunity, within 14 days, only when rather severe lung-lesions have been produced. An inapparent infection with a mouse-passage strain does not result in immunity.

After intranasal inoculation with tissue-culture or ferret-passage strains of virus, mice may become immune to the homologous mouse-passage strain without having had visible lung-lesions as a result of the immunizing procedure.

With the ferret-passage strains 1/100,000 of an MLD suffices to produce immunity while with the mouse passage strains 1/10 to 1/100 of an MLD is required.

Per unit of infected tissue, mouse-passage strains are much more virulent for mice than are ferret-passage or tissue culture strains, but the former possess only a little more immunizing capacity by the intranasal route than ferret-passage or tissue-culture virus.