HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Morgan, I. M. Articles by Olitsky, P. K. Search for Related Content PubMed Articles by Morgan, I. M. Articles by Olitsky, P. K.

A Study of Immunity in Rabbits from Two to Three Years After Infection with Vaccine Virus with Attempts to Recover Active Virus

Laboratories of The Rockefeller Institute for Medical Research, New York

Abstract

1. Of 4 rabbits tested for active immunity nearly 3 years after vaccinal infection, 1 was not immune, 1 showed a slight, and 2 a moderate degree of resistance to cutaneous reinfection.

2. No active virus was recovered from 2 to 3 years after vaccinal infection from selected tissues of the 7 rabbits studied. From the testes of 1 of these animals and the spleen of 2 others, no virus had been detected after 1 year. However, from a skin scar but not from the spleen of 1 rabbit, vaccine virus had been recovered 3 months after infection.

3. Sera from the 7 rabbits, about 2 years after the last vaccinal infection, neutralized from 10 to 10,000 minimal skin doses of vaccine virus.

4. Sera from 2 of the 7 rabbits, more than 2 years after last infection, showed agglutinins to vaccinal elementary bodies to a titer of 1:16; the other 5 sera showed none. No precipitins to dermal filtrate were found in any of the sera.

5. The results are discussed with reference to the problem of persistence of virus and duration of immunity.