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The Effect of Age on the Spread of Dye in the Skin of Normal, Antigenically Stimulated, and Tuberculous Guinea Pigs

From the Bureau of Laboratories, Michigan Department of Health, Lansing, Michigan

Abstract

1. The rate of spread of trypan blue in the skin of old normal guinea pigs is less than in young normal guinea pigs.

2. The rate of spread of dye in old animals is not influenced by tuberculosis, but in young guinea pigs tuberculosis retards the rate of spread of intradermally injected dye.

3. Immunization with alum precipitated toxoid does not influence the rate of spread of dye in young guinea pigs.

4. Subcutaneous or intraabdominal injection of dead tubercle bacilli into young guinea pigs retards the rate of spread of dye as compared with the rate in young normal animals.