HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Powell, H. M. Articles by Clowes, G. H. A. Search for Related Content PubMed Articles by Powell, H. M. Articles by Clowes, G. H. A.

Further Inoculation-Experiments with the Common-Cold Virus

From the Lilly Research Laboratories, Indianapolis, Indiana

Abstract

1. Cold-virus has not proved fatal for Swiss mice when passaged in series. A few fatalities were due to associated bacteria.

2. Cold-virus passage in ferrets has been followed in several instances by depression of body-temperature. The specificity of this has not been proven. No leucocytic reactions were observed.

3. Both attenuated (formalin-treated) and raw viruses have been used hypodermically and intranasally in a total of 83 adult persons.

4. The hypodermic use of cold-virus vaccine appears fairly safe; however intranasal use seems sometimes to cause colds.

5. An irregular degree of immunity to inoculation colds may be imparted by the use of cold-virus vaccine.

6. The evidence thus far obtained in small groups of adult subjects indicates the ineffectiveness of cold-virus vaccine in preventing natural colds.