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Cutaneous Reactivity of Guinea Pigs to Gum-Arabic

Boston

Abstract

Evidence of an allergic response to gum-arabic as measured by cutaneous reactivity has been demonstrated in both tuberculous and normal guinea pigs after repeated intracutaneous tests with tuberculin diluted with acacia. That this sensitization is dependent upon a true antigen-antibody reaction is shown by positive anaphylactic and precipitin reactions. Although chemical analysis of gum-arabic points to the possibility of a protein fraction, further investigation is necessary to establish the chemical nature of the sensitizing fraction of acacia. Reports by other investigators call attention by inference to a protein or proteid substance, which is responsible for the antigenic activity of gumarabic. This study calls into question the use of a tuberculin solution containing gum-arabic in epidemiological and immunological work.