HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Scherp, H. W. Search for Related Content PubMed Articles by Scherp, H. W.

Studies on Meningococcal Infection

XI. A Quantitative Study of the Precipitative Reaction Between Type I Polysaccharide and Antimeningococcal Horse Sera¹

From the Departments of Pediatrics and Bacteriology, School of Medicine, University of Pennsylvania, Philadelphia, Pa., the Children's Hospital of Philadelphia, and the Department of Bacteriology, School of Medicine and Dentistry, University of Rochester, Rochester, New York

Abstract

The immunological properties of a polysaccharide prepared from type I meningococci and of antimeningococcal horse sera were studied by means of a quantitative analysis of the precipitative reaction. The results showed that the polysaccharide was a mixture of precipitinogens, and was therefore not immunologically pure, as was previously thought. The data indicated that the polysaccharide contained not only a type-specific component but also a considerable proportion of a group-specific one; that the monovalent type I serum which was studied contained only type-specific antibody; and that the polyvalent sera which were studied contained more group- than type I-specific antibody.

Footnotes

¹ Presented in part before the Society for Pediatric Research, Atlantic City, N. J., May 4, 1937.