HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Weil, A. J. Articles by Clapp, F. L. Search for Related Content PubMed Articles by Weil, A. J. Articles by Clapp, F. L.

Behavior of Acid-Treated Antipneumococcal Rabbit Antibodies

Lederle Laboratories, Inc., Pearl River, N. Y.

Abstract

1. Pneumococcal rabbit antibody treated with acid shows an increase of nitrogen precipitable by S.

2. A shift in the combining ratio occurs at the same time.

3. The ratio of mouse-protective value / N precipitated by S is lowered.

4. The complement-fixing quality of acid-treated sera is impaired or lost when the ratio of mouse-protective power / N precipitable is lowered. Loss of complement-fixing quality was also observed with antibody subjected to a process of partial peptic digestion.

5. The properties of causing capsular swelling and of eliciting passive anaphylactic shock are unimpaired in acid-treated sera.

6. The implications of these observations are discussed.

Footnotes

¹ The technical part of this investigation was divided as follows: A. M. Moos is responsible for the chemical work, F. L. Clapp for the tests with mouse-protection and capsular swelling, and A. J. Weil for the remainder.