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The Bactericidal Effect of Sulfanilamide upon Pathogenic and Non-Pathogenic Staphylococci¹

Division of Internal Medicine, University of Minnesota Medical School and Hospital, Minneapolis, Minnesota

Abstract

1. The bactericidal effect of sulfanilamide upon nineteen strains of staphylococci was studied. Twelve strains belonged to the pathogenic group, and seven were considered nonpathogenic.

2. Sulfanilamide in high concentrations had little or no bactericidal effect upon organisms suspended in peptone-broth and incubated at 37°C. When the mixtures of organisms and the drug were incubated at 40°C., the bactericidal effect was more pronounced.

3. Sulfanilamide was bactericidal for all the strains, when the organisms were suspended in urine. The maximum effect took place at an incubation of 40°C., and was not dependent upon the initial pH of the urine.

4. The presence of small quantities of added peptone in urine completely interfered with the bactericidal action of the drug. The significance of this action of peptone is discussed.

Footnotes

¹ Presented in part at the annual meeting of the American Society for Clinical Investigation, Atlantic City, May 1, 1939.

Aided by a grant from the Graduate School of the University of Minnesota.

This article has been cited by other articles:

				W. W. SPINK, A. E. HANSEN, and J. R. PAINE STAPHYLOCOCCIC BACTEREMIA: TREATMENT WITH SULFAPYRIDINE AND SULFATHIAZOLE Arch Intern Med, January 1, 1941; 67(1): 25 - 35. [Abstract] [PDF]