HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Farmer, L. Search for Related Content PubMed Articles by Farmer, L.

Experiments on Histamine-Refractoriness

II. Non-specific "Desensitization" Through Oral Application of Histamine

Allergy Clinic and the Achelis Laboratory, Lenox Hill Hospital, New York City

Abstract

1. The uterine strips of normal guinea pigs that had received histamine by mouth were less sensitive to histamine than were the uterine strips of the untreated controls.

2. The uterine strips of serum-sensitized guinea pigs that had received histamine by mouth at the height of sensitization were less sensitive to the specific antigen than were the sensitized uterine strips of the control animals.

3. These experiments demonstrate (a) that histamine-refractoriness can be induced in normal guinea pigs through oral application of histamine; (b) that it is possible to "desensitize" sensitized guinea pigs non-specifically through oral application of histamine.

4. The observations recorded under 3(b) confirm the conclusion previously (1) arrived at that "histamine is the substance responsible for the anaphylactic contraction of plain muscle."

This article has been cited by other articles:

				L. M. SMITH HISTAMINE IN TREATMENT OF ATOPIC DERMATOSES Arch Dermatol, November 1, 1941; 44(5): 883 - 890. [Abstract] [PDF]

				F. M. RACKEMANN ALLERGY: A REVIEW OF THE LITERATURE OF 1939 Arch Intern Med, January 1, 1940; 65(1): 185 - 212. [Abstract] [PDF]