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The Journal of Immunology, 1939, 37: 41-45.
Copyright © 1939 by The American Association of Immunologists, Inc.
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The Polyvalency of Crotalidic Antivenins

II. Comparison of Polyvalent Crotalidic Antivenin with Monovalent Crotalus D. Durissus Antivenin

Thomas S. Githens and Nigel O'C. Wolff

Mulford Biological Laboratories, Sharp and Dohme, Glenolden, Penna.

Abstract

1. Those North American pit viper venoms which induce delayed paralysis are strongly neutralized by a monovalent antivenin prepared against a similarly acting venom.
2. It is suggested that this may indicate a distinctive neurotoxic constituent in these venoms.
3. All other North American pit viper venoms are better neutralized by a polyvalent antivenin.






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