HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Strumia, M. M. Articles by Neher, R. N. Search for Related Content PubMed Articles by Strumia, M. M. Articles by Neher, R. N.

Immunological Studies in Active Vaccination against Scarlet Fever¹

Clinical Laboratory of the Bryn Mawr Hospital, Bryn Mawr, Pennsylvania

Abstract

The literature before 1930 on active immunization against scarlet fever has been summarized by Thomson and Thomson (1). Rector (2), also, has recently studied statistical data covering about 60,000 individuals inoculated with Dick toxin in which there was an attack rate of 0.5 per cent for the immunized individuals as against 14 per cent for the known susceptibles. Anderson's (3) statement, therefore, appears to be true that "Immunization with Dick toxin in adequate doses confers on a person previously susceptible a level of resistance against clinically recognizable scarlet fever comparable to that shown by a negative test."

Granted then that most investigators agree on this point, considerable disagreement nevertheless exists as to whether active immunization against scarlet fever protects against the erythrogenic toxin only, or whether it also increases resistance to the invasiveness of the streptococcus and to other manifestations of the infection.

Footnotes

¹ The work reported in this communication was carried out under a special fund established by Mrs. John S. Sharpe, and Mr. and Mrs. T. C. Colket 2nd.