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The Sensitization of Guinea Pigs to Amidopyrine¹

Department of Bacteriology and Immunology, Washington University School of Medicine, St. Louis, Mo.

Abstract

Landsteiner and Jacobs have shown that the following compounds are capable of producing hypersensitivity in laboratory animals: 2:4 dinitrochlorbenzene, paranitrosodimethylaniline, para-aminophenol, picryl chloride (1), arsphenamine (2), etc. One of us (3) repeated the sensitizing procedures using 2:4 dinitrochlorbenzene. Madison and Squier (4), as well as Benjamin (5), and others have brought forth evidence that hypersensitivity to amidopyrine exists in persons who have recovered from agranulocytosis. Patch and intracutaneous tests with amidopyrine gave positive reactions in such cases.

Assuming that the allergic response in a given species is independent of the allergen, and is only modified by the route of the injection of the exciting substance, one would not expect the allergic response to amidopyrine to produce agranulocytosis, while no such response exists to other allergens. We include red cell, white cell, and differential counts in our present report, as well as in a previous report on the hypersensitivity to 2:4 dinitroparachlorbenzene (3).

Footnotes

¹ Abstract of a paper presented for the Alexander Berg Prize in Bacteriology, Washington University Medical School, St. Louis, Mo.