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A Soluble Edema-Producing Substance from the Pneumococcus¹

From the Department of Medicine, University of Chicago, Chicago

Abstract

The appearance of tissue reactions of an edematous nature has been described, occurring in the skin or the lungs of puppies following the injection of (a) sterile or filtered broth in which pneumococci had grown for periods as short as 4 hours and as long as 72 hours; (b) extracts of autolyzed bacteria, obtained from broth cultures of similar ages; (c) sterile dog serum in which pneumococci had grown, and (d) fluids obtained from pulmonary pneumococcal infection in the same animal species. The edema-producing property is stable when heated at 100°C. for 2 hours and to prolonged preservation. It is not dialyzable. It is precipitable by full saturation with sodium sulfate. It is not associated with the type specific characteristic of the pneumococci. It is probably not antigenic.

Footnotes

¹ This study was aided by the Barlett Memorial Fund and the Douglas Smith Foundation for Medical Research, University of Chicago, Chicago.