HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ecker, E. E. Articles by Wertheimer, D. Search for Related Content PubMed Articles by Ecker, E. E. Articles by Wertheimer, D.

The Effect of Ascorbic Acid on the Constitution of Complement

Institute of Pathology and the University Hospitals, Western Reserve University, Cleveland, Ohio

Abstract

Ascorbic acid has no reactivating effect on end- or mid-piece of complement. On the reconstructed complement (mid- + end-piece) ascorbic acid produces an increased action.

Complement denatured by yeast is improved by the addition of ascorbic acid.

Ascorbic acid has no effect on complement treated by ammonia.

After inactivation of complement of 5 minutes at 55°C. the serum is not improved by the addition of ascorbic acid.

The inactivation of complement by shaking in air or in vacuo is in all probability a physical process and such inactivation is, so far as ascorbic acid is concerned, irreversible. Aeration of complement by air reduces its activity. This reduced activity can be markedly restored by the addition of ascorbic acid.