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The Journal of Immunology, 1938, 34: 19-37.
Copyright © 1938 by The American Association of Immunologists, Inc.

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Ascorbic Acid and Complement Function

E. E. Ecker, L. Pillemer, D. Wertheimer and H. Gradis

Institute of Pathology and the University Hospitals, Western Reserve University, Cleveland, Ohio

Abstract

A correlation has been shown to exist between the concentration of ascorbic acid in the blood serum of guinea pigs and the complementing activity of the serum.

In vivo, this parallelism holds true until a definite level of ascorbic acid is reached at about 1 mgm. per 100 cc. of serum.

Serums treated in vitro with optimum quantities of ascorbic acid show a distinct rise of complementing activity and increased stability.




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