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The Journal of Immunology, 1937, 33: 407-418.
Copyright © 1937 by The American Association of Immunologists, Inc.

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Anaphylaxis with Tobacco Mosaic Virus Protein and Hemocyanin

C. V. Seastone, Hubert S. Loring and K. Starr Chester1

From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey

Abstract

The anaphylactic properties of the tobacco mosaic virus protein and the hemocyanin of Limulus polyphemus have been studied in sensitized guinea pigs in vivo and by means of the Schultz-Dale method.

The results demonstrate that the tobacco mosaic virus protein is anaphylactogenic when tested in vivo, but in agreement with previously published data fails to cause smooth muscle contraction when tested in vitro.

The results of the experiments with the hemocyanin of Limulus polyphemus demonstrate that this protein is anaphylactogenic when tested by either of the above methods.

Footnotes

1 The in vivo experiments were carried out by C. V. S. and H. S. L.; the in vitro tests by K. S. C.







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