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Fractions of the Human Group-Specific A-Antigen¹

Biological Laboratory, Brown University, Providence, Rhode Island

Abstract

Four fractions of the group-specific A-antigen of human erythrocytes were distinguished by their reactions with various types of normal and immune A-agglutinins as follows: 1, a thermostable, alcohol-soluble fraction whose serologically reactive group was present in pepsin but not in sheep-erythrocytes; 2, a thermostable, alcohol-insoluble fraction whose reactive group was likewise present in pepsin but not in sheep-cells; 3, a thermostable, alcohol-soluble fraction whose reactive group was present both in pepsin and sheep-erythrocytes; and 4 a thermolabile, alcohol-labile fraction present neither in pepsin nor sheep-cells. The fourth component has the properties of an isophilic antigen and possibly is the A-antigen restricted in distribution to human A- and AB-individuals.

Footnotes

¹ This work was supported in part by a grant from the Rockefeller Foundation.