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A Study of the Pneumococcic Toxins and Antitoxins in Animals¹

From the Lederle Laboratories, Incorporated, Pearl River, New York

Abstract

1. The skin-test-dose of the toxins of the pneumococcus in human beings is about the same as that in the skin of susceptible rabbits.

2. Twenty per cent of the usual laboratory rabbits are susceptible to these toxins; but nearly all of the breed of rabbit known as "Havana red" are susceptible.

3. Elevation of temperature is caused by the intra-abdominal injection of toxin of the pneumococcus into rabbits in quantities of 3,000 skin-test-doses or more; 15,000 skin-test-doses failed to kill.

4. With the use of a highly concentrated toxin, the lethal dose for the mouse (16,000 skin-test-doses) could be established (intra-abdominal injection).

5. Antitoxin capable of specific neutralization of the respective toxin could be produced in rabbits.

6. Tests of comparative toxicity of scarlatinal and pneumococcal toxins in mice showed the former to be twice as strong as the best type III pneumococcic toxin available at the time.

Footnotes

¹ Read before the Seventh Meeting of the New York City Branch, Society of American Bacteriologists, October 13, 1936.