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Precipitin Reactions Between Hemolytic Streptococci of Various Groups and Immune and Rheumatoid Arthritic Sera

From the Department of Medicine, New York University College of Medicine, and the Third (New York University) Medical Division, and the Laboratories of Pathology, Bellevue Hospital, New York City

Abstract

Cross-reactions were obtained with crude C-extracts of hemolytic streptococci of various groups used in precipitative tests with immune human and rabbit sera and sera of patients with rheumatoid arthritis, rheumatic fever and convalescent scarlet fever. From the results obtained it seems probable that these cross-reactions were due to the presence in such sera of antibodies against a non-group-specific fraction or radical present in the bacteria and in the crude C-extracts. Evidence was obtained indicating that this substance is not the "nucleoprotein" fraction P and suggesting that it is of non-proteic nature.