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The Localization and Concentration of Blood-Borne Antibodies and Colloidal Dye in Areas of Inflammation of Various Ages

From the Department of Pathology of the University of Chicago

Abstract

The above experiments were undertaken to determine (a) whether antibodies may be localized from the blood-stream in areas of inflammation, and (b) the relationship existing between the stage of the inflammatory process and its ability to localize any blood-borne materials.

Inflammatory lesions of various ages were created in rabbit-skin with three types of irritants, and large doses of test-materials (trypan blue, hemolytic and agglutinating sera) were injected intravenously. It was found that the youngest lesions localized the dye more rapidly, and in greater amounts than the older lesions. Further, the power to localize blood-borne materials was found to persist for a longer time in lesions produced with the stronger irritants. This was correlated with the persistence of a granulation-type of reaction about areas of local breakdown of tissue. Where such breakdown did not occur, the property of localization was lost after 24 hours, apparently because of vascular interference.

The localization of antibody was less conclusively demonstarted, but in view of certain considerations indicated, it was presumed to occur. A correlation, similar to that noted with the dye, was observed to exist between the localization of antibody and the age and severity of the inflammatory lesions. No evidence was found suggesting that antibody might be more easily localized in inflammatory sites induced by the specific antigen.