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Active Immunization against Poliomyelitis. A Comparative Study¹

II. Experimental Immunization of Monkeys with Virus Treated with Sodium Ricinoleate

From the Laboratory of the Infantile Paralysis Commission of the Long Island College of Medicine

Abstract

We have been unable to obtain evidence of attenuation of the poliomyelitis virus by 1 per cent sodium ricinoleate.³

Thirty animals received 5 doses each by subcutaneous inoculation at weekly intervals. Sixteen of the animals developed sufficient neutralizing substance in their blood to neutralize a single constant infective dose of virus. All but 2 succumbed to the intracerebral inoculation of the same dose of virus.

Footnotes

¹ This work is supported by grants from the Rockefeller Foundation, the Friedsam Foundation, and by a grant from the President's Birthday Ball Commission for Infantile Paralysis Research.

³ In a personal communication Kolmer agreed with us that no appreciable attenuation occurred.