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The Behavior of Immediate and Delayed Cutaneous Reactions to Bacterial Nucleo-Proteins in Asthmatic Patients

From the Department of Medicine of the College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York City

Abstract

Studies of the cutaneous reactions to bacterial nucleoproteins in asthmatic patients have been in progress for several years and the results obtained on testing 100 consecutive patients on admission have been tabulated and analyzed in a previous publication (1). Immediate and delayed reactions occurred in these patients, and although both types of reaction were obtained simultaneously with different bacterial proteins in the same patient, an immediate reaction to a bacterial protein was seldom combined with a delayed response at the site of the same bacterial inoculation. In a few patients retested on several occasions some reactions were transient while others were persistent but tests done at one time failed to indicate with certainty the types of reaction and the bacteria to which a patient might react later. The retesting has been continued. Table 1 shows the results with a number of patients studied intensively over a period of years.