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Comparison of the Bactericidal Action of Human and Guinea-Pig Blood on Strains of the Meningococcus with the Mouse-Mucin Test for Virulence

From the Connaugth Laboratories, University of Toronto, the Wards and Laboratories of the Hospital for Sick Children and the Department of Paediatrics

Abstract

In 1934 the authors (1) reported on the bactericidal action of samples of human blood on strains of the meningococcus. It was found that a sample of blood possessing no bactericidal power against a cerebrospinal fluid strain of the meningococcus behaved in a different manner towards nasopharyngeal strains from noncontact carriers. In a later article in 1935 they (2) demonstrated the specificity of this property and showed that it could be induced in the blood of guinea pigs by vaccination. During the latter part of 1935 and 1936 these studies on the bactericidal effect of samples of human blood on various strains of the meningococcus were extended. The bactericidal action of human and guinea-pig blood has been compared with the virulence of strains when tested by means of the mouse-mucin test described by Miller (3).