HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kopeloff, N. Articles by Kopeloff, L. M. Search for Related Content PubMed Articles by Kopeloff, N. Articles by Kopeloff, L. M.

General and Cerebral Anaphylaxis in the Monkey (Macacus Rhesus)

From the Department of Bacteriology, New York State Psychiatric Institute and Hospital, New York

Abstract

1. Fatal anaphylactic shock has been produced at will in monkeys following single or multiple preparatory intravenous injections of liberal amounts of fresh undiluted egg-white and in one instance by sensitization through the gastro-intestinal route.

2. Passive transfer of rabbit anti-egg-white serum to a single monkey resulted in anaphylactic death upon injection of antigen.

3. Local cerebral anaphylaxis as evidenced by contralateral focal symptoms and pathologic brain changes including necrosis have been observed in sensitized monkeys upon subsequent injection of the specific antigen.

4. The pathologic picture of fatal anaphylaxis in monkeys is markedly different from that seen in any of the usual laboratory animals.