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Carbohydrate-Containing Proteins of the Hemolytic Streptococcus¹

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York City

Abstract

1. A modification of earlier methods is given for the microdetermination of carbohydrate in protein.

2. Scarlatinal streptococcus protein fractions contain, in general, more carbohydrate than can be accounted for by their nucleic acid content and quite regularly give rise to anticarbohydrate as well as antiprotein when injected into rabbits.

3. Evidence is presented that the non-nucleic acid carbohydrate of the protein fractions is chemically combined "C" substance.

Footnotes

¹ The work reported in this communication was carried out under the Harkness Research Fund of the Presbyterian Hospital and was read in part at the meeting of the American Chemical Society, New York City, April, 1935.