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Observations on Abnormal Isoantibodies Following Transfusions

From the Bacteriological and Serological Laboratories of the Beth Israel Hospital, New York City

Abstract

There can be no doubt that all human beings may be classified as belonging to one of the four blood groups of Landsteiner. However, recent investigations have shown that sub-groups exist within these four main blood groups, especially within the group A. Moreover, specific antigens can be demonstrated in red blood cells which are not at all related to the group properties A and B (e.g., factors M, N and P of Landsteiner and Levine). They can be demonstrated only by means of immunization of rabbits with human blood cells containing the respective substances. There are no corresponding normal antibodies present in human serum. Ehrlich and Moregenroth were the first to produce specific isoagglutinins in goats by means of immunization. There are a few reports in the literature concerning specific isoagglutinins in men caused by immunization. Landsteiner, Levine and Janes (1) observed abnormal agglutinins in man after blood transfusions from donors of the same group.

Footnotes

¹ Aided by a Grant of the Emanuel Libman Fellowship Fund.