HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Merrill, M. H. Search for Related Content PubMed Articles by Merrill, M. H.

Quantitative Studies on the Neutralization of Equine Encephalomyelitis Virus by Immune Serum

I. Combination of Virus and Antibody in Vitro

From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey

Abstract

1. When equine encephalomyelitis virus and a subneutralizing dose of immune serum were mixed and then diluted the titer by intracerebral inoculation was from 10 to 100 times below the titer of the same materials mixed after dilution.

2. When virus was inactivated by mixing with immune serum all dilutions of the mixture were noninfective upon intraperitoneal inoculation. When each was diluted before mixing, animals receiving the higher dilutions were not protected.

3. The filterability of the virus was diminished by mixing with subneutralizing doses of immune serum.

4. It is concluded from these results that the virus and immune body combined in vitro. It is considered probable that aggregation of the virus particles occurred.