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Effect of Gonadotropic and Oestrogenic Hormones on Agglutinin Response to B. Pertussis in Immature Animals

From the Department of Bacteriology and the Research Laboratories, The Upjohn Company, Kalamazoo, Michigan

Abstract

Immature rats and rabbits did not respond to injections of B. pertussis and B. typhosus with the high degree of agglutinin production obtained in mature animals of these species. A general correlation existed between agglutinin titer, body weight, and sexual development (as indicated by testes and seminal vesicle weights), and their rates of increase with age in rats injected with B. pertussis.

Gonadotropic hormone obtained from pregnant mare serum, prolan, theelin, or pituitary implants do not influence agglutinin production in immature or infantile rats or rabbits in the doses administered, although such administration in rats does produce definite development of the gonads and accessories.