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The Standardization of Antidysenteric Serum (Shiga) by the Polysaccharide Precipitating Test (Zozaya)

From the Serological Department (K. Kurauchi), Hygienic Institute (Director, K. Audo), of the South Manchuria Railway Company, Dairen, Manchuria

Abstract

The proper use of any therapeutic serum demands some reliable methods of measuring its potency. For various reasons, the problem is essentially more intricate in this case than in that of diphtheria and tetanus serums. The International Serum Conference held in 1921–1928, on the invitation of the Health Section of the League of Nations, has enabled the most important points to be cleared up, and now has provided a sound basis for the standardization of the dysentery serum (Shiga), and has provisionally adopted the international antitoxin unit of the serum.

In studying the polysaccharide of different organisms, we (1) have succeeded in isolating the polysaccharide from B. dysenteriae (Shiga) and also B. paradysenteriae (Flexner Strong, Y. and others). Later Morgan (2) published a method of obtaining polysaccharide from B. dysenteriae (Shiga).

The polysaccharide precipitation method for determining the potency of antipneumococcus serum has been employed satisfactorily by many authors (Friedlaender, Sobotka and Banzhaf, Heidelberger, Sia and Kendall, Zozaya, Boyer and Clark, Felton, Wilson Smith, Brown, etc.).