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Studies on the Chemical Nature of Shwartzman-Active Substances

Department of Bacteriology and Immunology of the Harvard University Medical School

Abstract

1. Shwartzman-active substances are contained in two different chemical fractions of bacterial substances.

2. The so-called "nucleoprotein" fraction is always found to be Shwartzman-active; it is derived from bacterial autolysis or extraction. Its potency is increased in alkaline solution.

3. Most of the potency of agar-washings is connected with an alcohol-precipitable biuret-negative fraction. The appearance of these Shwartzman-active substances does not depend on autolytic processes, but is metabolic in character.

4. The Shwartzman-active substances of the last described fraction are highly unstable, precipitable with small volumes of alcohol and not identical with type-specific carbohydrates.

5. The Shwartzman-active factor of filtered washings is slowly dialyzable and resists trypsin digestion.

Footnotes

¹ This work was done while the author held a fellowship from the Rockefeller Foundation.