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Hemorrhagic Reaction at the Site of Injection of Toxins After Intravenous Injection of Starch in Young and Adult Rabbits

From the Department of Pathology, Cornell University Medical College

Abstract

When certain bacteria or their products are injected into the skin of rabbits and on the following day the same material is injected into the blood stream, hemorrhage or hemorrhagic necrosis results in the skin at the site of the first injection (Shwartzman (1), Hanger (2)). The nature of this reaction, called the Shwartzman phenomenon, is not understood.

It seems to be significant from the point of view of the mechanism of the reaction that Sickles (3) was able to show that the bacterial toxins of the second (intravenous) injection can be replaced by a suspension of agar. Shwartzman (4) found that when a mixture of precipitinogen and serum containing homologous precipitin is injected into a vein hemorrhage follows in the skin in an area prepared by bacterial filtrates. It was reported recently (5) that the introduction of 10 cc. of a 10 per cent starch solution into the blood stream causes hemorrhage in the skin at the site of injection of bacterial filtrates or eelserum.