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The Cytotoxic Principle in Anti-Euglena Rabbit Serum¹

From the Department of Bacteriology, University of Kansas, Lawrence

Abstract

The presence of a specific cytotoxic principle in anti-euglena rabbit serum which does not require serum complement for its action has been confirmed. The cytotoxic effect of anti-euglena serum is enhanced by the presence of complement. The cytotoxic principle behaves like a true antibody in its specificity and absorption reactions, and in its association with the non-dialyzable globulin constituents of serum. Electrolytes may not be necessary for the reaction. Immune rabbit serum containing the cytotoxic principle passively sensitizes guinea pigs to the homologous organism.

Footnotes

¹ Submitted to the Department of Bacteriology and the Faculty of the Graduate School in partial fulfillment of the requirements for the degree of Doctor of Philosophy.