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Experiments on Reactivation of the Virus in Neutral Serum-Virus Mixtures

From the Bacteriological Department, University of Edinburgh

Abstract

1. Antigen-antibody union occurring in vitro was demonstrable in overneutralised serum-virus mixtures.

2. More or less balanced mixtures were reactivable. There was no evidence of in vitro union in such mixtures.

3. The speed of inactivation of the virus was unlike the slow neutralisation of a toxin by the corresponding antitoxin and could be compared to the destruction of bacteria by specific antisera.

4. Inactivation of the louping-ill virus in vivo by the corresponding antiserum could be effected without any in vitro contact.

No major differences have been elicited between the mechanism of anti-viral and anti-bacterial immunity.