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Post-Anaphylactic State in Guinea Pigs

New York City

Abstract

1. Sensitized guinea pigs which received on reinjection a sublethal dose of antigen and therefore survived the anaphylactic shock, are in a pathological state.

2. As a rule, this characteristic post-anaphylactic state is easily discovered on the seventeenth day after the reinjection of the antigen. It is expressed in sharply changed reactions of animals to various chemical preparations, e.g., to azo-compounds, and in particular to chrysoidin (2.4-diaminoazobenzol). Subcutaneous injection of chrysoidin produces in these animals a peculiar reaction the symptoms of which greatly resemble those of acute anaphylactic shock in rabbits.

3. In the post-anaphylctic state guinea pigs tolerate some chemical preparations, and in particular chrysoidin, in considerably smaller quantities than do normal animals.

4. The post-anaphylactic state of guinea pigs changes into normal state by itself not later than thirty-one days after the shock.

5. Timely injections of some anti-shock preparations prevent not only the anaphylactic shock, but likewise the post-anaphylactic state of guinea pigs. To these preparations belong: (a) phenylmethylpyrazolone; (b) phenyldimethylpyrazolone (antipyrine); (c) di-phenylmethylpyrazolonyl (Rossium); (d) the sodium salt of Phenyldimethylpyrazolonylaminomethylene sulphonic acid (melubrine); (e) methyloxindol; (f) alpha-phenyl-alpha-acetyl-hydrazine.