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The Individual As a Factor in Antidiphtheria Immunity

II. Titers of Individual Guinea Pigs at Times Remote from the Last Injection of Antigen

From the Department of Bacteriology and Immunology of Cornell University Medical College, New York, and the Department of Bacteriology and Immunology of Vanderbilt University Medical School, Nashville

Abstract

The investigation was essentially an analysis of the antitoxin titers of the sera of a large number of guinea pigs immunized by different methods and bled at 6-month intervals between the first and third year following the last injection.

The data indicated that the individual animal is a more important factor than the method of immunization in determining the titer of antitoxin possessed at times remote from the last injection. Examples were given of the wide differences in individual guinea pigs in respect to their loss of antitoxin. Some individuals had such a marked capacity to maintain their immunity that their titers appeared approximately "level" over long periods; the time at which this "level" was reached and the height at which it was maintained appeared to be as much a characteristic of the individual guinea pig as of the method of immunization.