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The Rôle of Convalescent Serum in Preparalytic Poliomyelitis

From the Department of Bacteriology, New York University and Bellevue Hospital Medical School and Bureau of Laboratories, Department of Health, New York

Abstract

1. The pathogenesis of poliomyelitis, as a disease transmitted by nerve fibers and entirely neurotropic, suggests the ineffectiveness of serum therapy.

2. Additional experimental data concerning the use of large quantities of serum, or whole blood, in the various stages of the disease, give further evidence to its lack of value.

3. Therefore, in serum therapy one is faced with two possibilities:

a. Antibody can never reach the virus in the central nervous system.

b. Still larger amounts must be used, e.g., hyperimmune horse serum, but from the data herewith given the likelihood of success with such a serum is slight.

Footnotes

¹ National Research Fellow. This work was supported by grants from The Rockefeller Foundation and New York Foundation.