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An Immunological Study of the Effects of Intense Sound Vibrations on Egg Albumin

From the Departments of Bacteriology and Pediatrics and the Johnson Foundation for Medical Physics, School of Medicine, University of Pennsylvania, Philadelphia

Abstract

1. The coagulum produced by sonic radiation of egg albumin solution has a much decreased antigenic activity and an altered specificity.

2. The altered specificity of the coagulum is similar to the specificity of albumin denatured in other ways.

3. The soluble fraction remaining after sonic radiation is unaltered immunologically.

4. Prolonged radiation increases the amount of coagulum produced and then redisperses it into an opalescent sol of the same altered serological specificity. Very prolonged radiation decreases the amounts of both serologically native and altered proteins.

5. Excellent agreement, both with respect to antigenic activity and specificity, was observed in the results with the Arthus phenomenon, the intradermal tests and in the precipitin reactions. In some cases the intradermal test was somewhat more delicate than the precipitin reaction.