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Some Observations on the Question of the Various Manifestations of Antibody Activity Being Due to Separate Antibodies or an Immune Substance Acting Differently Under Various Conditions

From the University College Hospital Medical School, London, England

Abstract

In this paper are recorded experiments bearing on the question of the different aspects in antibody activity being due to the action of a single immune substance or due to various types of antibody. The experiments deal with the problem by: (a) the study of the development of the various types of antibody activity, and (b) the study of differential adsorptions and differential temperature destructions.

Teale and Embleton (1913) showed that the lytic antibody passed through various stages during the course of its development before it became thermostable, viz., in the earliest stages it appeared as a type of specifically differentiated complement, then as a thermolabile immune substance activated by the non-specific complement and finally as the usually recognised thermostable antibody. In this paper these observations will be confirmed and extended and in addition it will be shown that although the lysins pass through phases mentioned, the agglutinin and protective properties are thermostable from commencement of their formation.