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A Quantitative Study of Serum Precipitin in Anaphylaxis in the Rabbit

From the Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York

Abstract

Doerr and Russ (1) were among the earliest workers to undertake any quantitative determinations on the relation of antigen to antibody in anaphylaxis. These investigators obtained the important information that there was apparently a complete parallelism between the ability of an immune serum to sensitize passively and its precipitin titer. They also observed the fact that the animals sensitized with serum precipitating in the highest dilutions could be shocked with the smallest amounts of antigen, whereas animals injected with serums in which little precipitin was present, gave little or no reaction even when large amounts of antigen were used to shock.

Friedberger (2) in an attempt to establish the relation of anaphylaxis to immunity assumed that a large volume of circulating antibodies might confer a state of "immunity" to anaphylaxis, since these circulating antibodies would bind the injected antigen and so protect the body cells.