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Susceptibility to Pneumococcus Infection as Measured by Species-Specific Agglutinins^1,2,

From the Research Laboratories, Department of Health, City of New York, the Pathological Laboratories, St. John's Hospital, Brooklyn, New York, and the Department of Pathology of New York University and Bellevue Hospital Medical College

Abstract

The variations in host response to controlled experimental infections have always offered a problem worthy of detailed investigation. The need for such investigation becomes increasingly important when such experimental infections form the basis for estimating the therapeutic efficiency of various antisera used in the treatment of specific bacterial infections. Thus in the course of studies on pneumococcus infection in rabbits after the method of Zinsser (1) and Goodner (2) it soon became apparent that the susceptibility of animals when measured by such factors as the size of the local lesion and the degree of blood stream invasion, varied within extremely wide limits, following upon injection of a relatively constant intradermal dose of virulent type I pneumococci. It was felt that a more detailed study of these experimental infections might throw some light on the question of host susceptibility.

Footnotes

¹ Aided by an appropriation from a grant made by the Simon Baruch Foundation for research in pneumonia.

² Presented in part at the meeting of the American Association of Pathologists and Bacteriologists at Washington in May, 1933.